Starting a GLP-1? These compounds are titrated — you ramp the dose up slowly so your body adapts and side effects stay manageable. Pick your compound below for a week-by-week schedule, or customize the start dose and step pace to match your protocol.
Titration means starting low and stepping up on a fixed schedule — it's how you avoid the worst of the nausea and GI side effects. Choose a compound for its standard ramp, then flip on Custom to set your own starting dose, step size, and how many weeks you hold at each step.
Starting at 1 mg can ease you in. The standard ramp starts at 2 mg, but a lot of people do better opening with 1 mg/week for the first few weeks — it gives your body a gentler on-ramp and tends to minimize the early nausea and GI side effects before you step up to 2 mg and beyond.
Diminishing returns past 8 mg. In the trial data, most of the fat-loss benefit is already captured by 8 mg/week — the jump from 8 to 12 mg added relatively little while side effects kept climbing. 12 mg isn't a finish line you have to reach; for many people 8 mg is the sweet spot for results vs. tolerability.
These schedules reflect clinical-trial protocols, not a prescription. Retatrutide is investigational and not FDA-approved — set your dose and pace with a qualified provider.
| Phase | Weeks | Weekly dose | Status |
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Every GLP-1 (and the amylin analog cagrilintide) is started low and stepped up on a schedule. The low starting dose isn't therapeutic — it's there to let your body adapt and blunt nausea, vomiting, and other GI effects. If a step hits you hard, holding it longer before moving up is normal and smart — the schedule is a guide, not a race.
This is an educational tool only and is not medical advice. Retatrutide is investigational and not FDA-approved; schedules shown reflect clinical-trial and community protocols, not a prescription. Dose, pace, and target must be set with a qualified healthcare professional. Compounds may be subject to legal and regulatory restrictions in your region.
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